Dr. Charles S. Grob

Co-Founder, Director of Clinical Research

Dr. Grob is currently Professor of Psychiatry and Pediatrics at the UCLA School of Medicine and the Director of the Division of Child and Adolescent Psychiatry at the Harbor-UCLA Medical Center. He has a long-standing interest in the history of psychiatric research with hallucinogens and has published in the psychiatric literature and has given talks at professional meetings in this area. Dr. Grob recently received the first FDA approval to carry out human research with 3,4-methylenedioxymethamphetamine (MDMA). He is presently collaborating with Dr. Dennis McKenna on a project to study the biochemical, physiological, and psychological parameters of long-term ayahuasca use in Brazil. In collaboration with Dr. Marlene Dobkin de Rios, he has examined the sociocultural context within which the use of these compounds occurs. In 2004 Dr. Grob initiated an FDA approved research investigation examining the effects of psilocybin on end-stage cancer patients with severe anxiety. He is also the editor of Hallucinogens: A Reader, published by Tarcher/Putnam in 2002, and the co-editor with Dr, Roger Walsh of Higher Wisdom: Psychedelics, Society, Mind and God, to be published by SUNY Press. Dr. Grob will work closely with the Scientific Advisory Panel to establish a clinical research program at the Institute.

Publications

Grob, C.S: Drug use and misuse in adolescence. The Journal of the California Alliance for the Mentally Ill 11:40-43, 2000.

Grob, C.S: Deconstructing ecstasy: The politics of MDMA research. Addiction Research 8:549-588, 2000.

Smith, L.M., Chang, L., Yonekura, M.L., Grob, C.S., Osborne, Ernst, T: Brain proton magnetic resonance spectroscopy in children exposed to methamphetamine in utero. Neurology 57:255-260, 2001.

Grob, C.S. Is U.S. drug policy on ecstasy scientifically justified? Journal of Addiction and Mental Health 5(2):17, 2002.

Grob, C.S, McKenna, D.J, Callaway, J.C, Brito, G.S, Neves, E.S, Oberlaender, G, Saide, O.L, Labigliani, E, Tacla, C, Miranda, C.T, Strassman, R.J. and Boone, K.S. Farmacologia humana da hoasca: effeitos psicologicos, in B.C. Labate and W.S. Araujo (Eds.), O Uso Ritual Da Ayahuasca, Campinas, Brazil, Mercado De Lettras, 2002.

Andrade, E.N, Brito, G.S, Andrade, E.S, Neves, E.S, McKenna, D.J, Cavalcante, J.W, Okimura, L, Grob, C.S. and Callaway, J.C. Farmacologica humana da hoasca: estudos clinicos, in B.C. Labate and W.S. Araujo (Eds.), O Uso Ritual Da Ayahuasca, Campinas, Brazil, Mercado De Lettras, 2002.

Grob, C.S. The politics of ecstasy. Journal of Psychoactive Drugs 34:143-144, 2002.

Cole, J, Sumnall, H. and Grob, C.S. Sorted: Ecstasy facts and fiction. The Psychologist 15:464-467, 2002.

Cole, J, Sumnall, H. and Grob, C.S. Where are the casualties? The Psychologist 15:474, 2002.

Dobkin de Rios, M, Grob, C.S. and Baker, J.R. Hallucinogens and redemption. Journal of Psychoactive Drugs 34:2390248, 2002.

Grob, C.S. (Ed.). Hallucinogens: A Reader, New York, Tarcher/Putnam, 2002.

Back-Madruga, C, Boone, K.B, Chang, L, Grob, C.S, Lee, A, Nations, H. and Poland, R.E. Neuropsychological effects of 3,4-methlyenedioxymetamphetamine (MDMA or ecstasy) in recreational users. The Clinical Neuropsychologist 17:446-459, 2003

Green, A.C. and Grob, C.S. Hyperactivity. In, Encyclopedia of the Neurological Sciences, Elsevier, 2003, pp. 604-608.

Grob, C.S. and Poland, R.E. MDMA. in J.H. Lowinson, P. Ruiz, R.B. Millman and J.G. Langrod (Eds.) Substance Abuse: A Comprehensive Textbook, 4th Edition. Baltimore, William & Eilkins, pp. 374-386, 2004.

Chang, L, Ernst, T, Speck, O. and Grob, C.S. Methamphetamine dependence exacerbates HIV-associated brain injury. American Journal of Psychiatry. In Press, 2004.

Chang, L, Cloak, C, Patterson, K, Grob, C.S, Miller, E.N. and Ernst, T. Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory response. American Journal of Psychiatry. In Press, 2004.

Grob, C.S. The enigma of ecstasy: implications for youth and society. Adolescent Psychiatry. In Press, 2004.

Walsh, R. and Grob, C.S. (Eds.). Higher Wisdom: Psychedelics, Society, Mind and God: Eminent Thinkers Reflect on the Continuing Impact and Implications of Psychedelics. Albany, New York, State University of New York Press. In press, 2005.

Chang, L.; Grob, C. S.; Ernst, T.; Itti, L.; Mishkin, F. S.; Jose-Melchor, R.; Poland, R. E. Effect of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] on cerebral blood flow: a co-registered SPECT and MRI study. Psychiatry Res. 2000, 98, 15-28.

Chang, L.; Ernst, T.; Grob, C. S.; Poland, R. E. Cerebral (1)H MRS alterations in recreational 3, 4- methylenedioxymethamphetamine (MDMA, "ecstasy") users. J Magn Reson. Imaging 1999, 10, 521-526.

Callaway, J. C.; McKenna, D. J.; Grob, C. S.; Brito, G. S.; Raymon, L. P.; Poland, R. E.; Andrade, E. N.; Andrade, E. O.; Mash, D. C. Pharmacokinetics of Hoasca alkaloids in healthy humans. J Ethnopharmacol. 1999, 65, 243-256.

Callaway, J. C.; Grob, C. S. Ayahuasca preparations and serotonin reuptake inhibitors: a potential combination for severe adverse interactions. J Psychoactive Drugs 1998, 30, 367-369.

Grob, C. S.; Greer, G. R.; Mangini, M. Hallucinogens at the turn of the century: an introduction. J Psychoactive Drugs 1998, 30, 315-319.

Poland, R. E.; Lutchmansingh, P.; McCracken, J. T.; Zhao, J. P.; Brammer, G. L.; Grob, C. S.; Boone, K. B.; Pechnick, R. N. Abnormal ACTH and prolactin responses to fenfluramine in rats exposed to single and multiple doses of MDMA. Psychopharmacology (Berl) 1997, 131, 411-419.

Callaway, J. C.; Raymon, L. P.; Hearn, W. L.; McKenna, D. J.; Grob, C. S.; Brito, G. S.; Mash, D. C. Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with ayahuasca. J Anal. Toxicol. 1996, 20, 492-497.

Grob, C. S.; McKenna, D. J.; Callaway, J. C.; Brito, G. S.; Neves, E. S.; Oberlaender, G.; Saide, O. L.; Labigalini, E.; Tacla, C.; Miranda, C. T.; Strassman, R. J.; Boone, K. B. Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil. J Nerv. Ment. Dis. 1996, 184, 86-94.

Grob, C. S.; Poland, R. E.; Chang, L.; Ernst, T. Psychobiologic effects of 3,4-methylenedioxymethamphetamine in humans: methodological considerations and preliminary observations. Behav Brain Res. 1996, 73, 103-107.

Callaway, J. C.; Airaksinen, M. M.; McKenna, D. J.; Brito, G. S.; Grob, C. S. Platelet serotonin uptake sites increased in drinkers of ayahuasca. Psychopharmacology (Berl) 1994, 116, 385-387.

Grob, C. S.; Bravo, G. L.; Walsh, R. N.; Liester, M. B. The MDMA-neurotoxicity controversy: implications for clinical research with novel psychoactive drugs. J Nerv. Ment. Dis. 1992, 180, 355-356.

Liester, M. B.; Grob, C. S.; Bravo, G. L.; Walsh, R. N. Phenomenology and sequelae of 3,4-methylenedioxymethamphetamine use. J Nerv. Ment. Dis. 1992, 180, 345-352.

Barnes, S. D.; Grob, C. S.; Lachman, B. S.; Marsh, B. R.; Loughlin, G. M. Psychogenic upper airway obstruction presenting as refractory wheezing. J Pediatr. 1986, 109, 1067-1070.

Grob, C. S.; Coyle, J. T. Suspected adverse methylphenidate-imipramine interactions in children. J Dev. Behav Pediatr. 1986, 7, 265-267.

Grob, C. S. Persistent supersensitivity vomiting following neuroleptic withdrawal in an adolescent. Biol. Psychiatry 1986, 21, 398-401.

Grob, C. S. Female exhibitionism. J Nerv. Ment. Dis. 1985, 173, 253-256.